Department of Toxicology
Poznan University of Medical Sciences
Wersja polskojezyczna

Marek Murias, Ph.D

phone: +48 61 8472081 ext.51

Main research interests:
resveratrol and its analogues,
toxicity of antioxidants,
apoptosis/necrosis in cancer cells,
metabolism of xenobiotics,




1.Regulski M., Regulska K., Stanisz B.J., Murias M., Gieremek P., Wzgarda A., Niżnik B., Chemistry and pharmacology of angiotensin-converting enzyme inhibitors, Curr. Pharm. Des. in press IF=3.288

2.Lijewski S., Gierszewski M., Sobotta L., Piskorz J., Kordas P., Kucinska M., Baranowski D., Gdaniec Z., Murias M., Karolczak J., Sikorski M., Mielcarek J., Goslinski T., Photophysical properties and photochemistry of a sulfanyl porphyrazine bearing isophthaloxybutyl substituents, Dyes and Pigments in press IF=3.468

3.Mikuła-Pietrasik J., Sosińska P., Kucińska M., M. Murias, Maksin K., Malinska A., Ziolkowska A., Piotrowska H., Wozniak A., Ksiazek K., Peritoneal mesothelium promotes the progression of ovarian cancer cells in vitro and in mice xenograft model in vivo, Cancer Letters, in press IF=5.016

4.Mikuła-Pietrasik J, Sosińska P, Murias M, Michalak M, Wierzchowski M, Piechota M, Sikora E, Książek K., Resveratrol Derivative, 3,3',4,4'-Tetrahydroxy-trans-Stilbene, Retards Senescence of Mesothelial Cells via Hormetic-Like Prooxidative Mechanism. J Gerontol A Biol Sci Med Sci. 2014 Sep 18. pii: glu172. [Epub ahead of print] IF=4.984

5.Licznerska B, Szaefer H, Matuszak I, Murias M, Baer-Dubowska W. Modulating potential of L-sulforaphane in the expression of cytochromes P450 to identify potential targets for breast cancer chemoprevention and therapy using breast cell lines, Phytotherapy Research, in press, IF 2.397

6.Regulska K, Murias M, Stanisz B, Regulski M, The mutagenicity analysis of imidaprilhydrochloride and its degradant, diketopiperazinederivative, nitrosation mixtures by in vitro Amestest with two strains of Salmonella typhimurium. Reports of Practical Oncology and Radiotherapy, in press,

7.Skupin-Mrugalska P, Sobotta L, Kucinska M, Murias M, Mielcarek J, Duzgunes N. Cellular changes, molecular pathways and the immune system following photodynamic treatment. Curr Med Chem. 2014 Aug 26. [Epub ahead of print] IF=3.715

8.Regulska K, Stanisz B, Regulski M, Murias M. How to design a potent, specific, and stable angiotensin-converting enzyme inhibitor. Drug Discov Today. 2014 Jul 3. pii: S1359-6446(14)00268-2. doi: 10.1016/j.drudis.2014.06.026. [Epub ahead of print] IF=5.964

9.Piotrowska H, Myszkowski K, Abraszek J, Kwiatkowska-Borowczyk E, Amarowicz R, Murias M, Wierzchowski M, Jodynis-Liebert J. DMU-212 inhibits tumor growth in xenograft model of human ovarian cancer. Biomed Pharmacother. 2014 May;68(4):397-400. IF=2.239

10.Cichocki M, Baer-Dubowska W, Wierzchowski M, Murias M, Jodynis-Liebert J. 3,4,5,4'-trans-tetramethoxystilbene (DMU-212) modulates the activation of NF-κB, AP-1, and STAT3 transcription factors in rat liver carcinogenesis induced by initiation-promotion regimen. Mol Cell Biochem. 2014 Jun;391(1-2):27-35. doi: 10.1007/s11010-014-1983-9. Epub 2014 Feb 13. IF=2,388

11.Kucinska M, Piotrowska H, Luczak MW, Mikula-Pietrasik J, Ksiazek K, Wozniak M, Wierzchowski M, Dudka J, Jäger W, Murias M. Effects of hydroxylated resveratrol analogs on oxidative stress and cancer cells death in human acute T cell leukemia cell line: prooxidative potential of hydroxylated resveratrol analogs. Chem Biol Interact. 2014 Feb 25;209:96-110 IF=2,91

12.Piotrowska H, Myszkowski K, Amarowicz R, Murias M, Kulcenty K, Wierzchowski M, Jodynis-Liebert J. Different susceptibility of colon cancer DLD-1 and LOVO cell lines to apoptosis induced by DMU-212, a synthetic resveratrol analogue. Toxicol In Vitro. 2013 Dec;27(8):2127-34. IF=3.207

13.Regulska K, Murias M, Stanisz B, Regulski M. Is there any association between imidapril hydrochloride stability profile under dry air conditions and cancer initiation? Int J Pharm. 2013 Nov 18;456(2):332-9 IF=3.785

14.Piotrowska H, Kucinska M, Murias M. Expression of CYP1A1, CYP1B1 and MnSOD in a panel of human cancer cell lines. Mol Cell Biochem. 2013 Nov;383(1-2):95-102. IF=2.388

15.Kaczmarek M, Jurczyk MU, Rubis B, Banaszak A, Kolecka A, Paszel A, Jurczyk K, Murias M, Sikora J, Jurczyk M., In vitro biocompatibility of Ti-45S5 bioglass nanocomposites and their scaffolds. J Biomed Mater Res A. 2013 May 29. in press, doi: 10.1002/jbm.a.34808, IF=2.63

16.Lijewski S, Piskorz J, Kucinska M, Wierzchowski M, Czerniak K, Billert H, Murias M, Mielcarek M, Goslinski T Synthesis, characterization, photochemical properties and cytotoxicity of the novel porphyrazine functionalized with nitroimidazolylbutylsulfanyl groups. Inorg Chem Comm, 2013, 29, 97 –100 IF=1,9

17.Geszke-Moritz M, Piotrowska H, Murias M, Balan L, Moritz M, Lulek J. Schneider R. Thioglycerol-capped Mn-doped ZnS quantum dot bioconjugates as effcient twophoton fluorescent nano-probes for bioimaging, Journal of Materials Chemistry B, 2013,1, 698-706 IF=5,9

18.Piotrowska H., Myszkowski K, Ziółkowska A, Kulcenty K Wierzchowski M., Kaczmarek M., Murias M, Jodynis-Liebert J. Resveratrol analogue 3,4,4',5-tetramethoxystilbene inhibits growth, arrests cell cycle and induces apoptosis in ovarian SKOV-3 and A-2780 cancer cells. 2012, Toxicology and Applied Pharmacology IF=3,99, 2012;263:53-60, IF=4.4

19.Dudka J, Gieroba R, Korga A, Burdan F, Matysiak W, Jodlowska-Jedrych B, Mandziuk S, Korobowicz E, Murias M., Different effects of resveratrol on dose-related Doxorubicin-induced heart and liver toxicity. Evid Based Complement Alternat Med. 2012;2012:606183. doi: 10.1155/2012/606183. Epub 2012 Nov 26 IF=4.7

20.Mikula-Pietrasik J. Kuczmarska A, Rubis B Filas V, Murias M, Piwocka K, Ksiazek K, Resveratrol delays replicative senescence of human mesothelial cells via mobilization of antioxidative and DNA repair mechanisms 2012, Free Radicals Biology and Medicine, 2012, 1-15;52(11-12):2234-45 IF=5.773,

21.Licznerska BE, Szaefer H, Murias M, Bartoszek A, Baer-Dubowska W. Modulation of CYP19 expression by cabbage juices and their active components: indole-3-carbinol and 3,3'-diindolylmethene in human breast epithelial cell lines. Eur J Nutr. 2012 10. 23

22.Mikuła-Pietrasik J, Kuczmarska A, Kucińska M, Murias M, Wierzchowski M, Winckiewicz M, Staniszewski R, Bręborowicz A, Książek K. 2012 Resveratrol and its synthetic derivatives exert opposite effects on mesothelial cell-dependent angiogenesis via modulating secretion of VEGF and IL-8/CXCL8. Angiogenesis. 2012 Sep;15(3):361-76. IF=6.188,

23.Piotrowska H, Kucinska M, Murias M. Biological activity of piceatannol: Leaving the shadow of resveratrol. Mutat. Res. 2011 Nov 17, Mutat. Res. Rev. 2012 Vol. 750 nr 1 s. 60-82 IF=8.741

24.M. Geszke, M. Murias, L. Balan, G. Medjahdi, J. Korczynski, M. Moritz, J. Lulek, R. Schneider Folic acid-conjugated core/shell ZnS:Mn/ZnS quantum dots as targeted probes for two-photon fluorescence imaging of cancer cells, Acta Biomaterialia, 2011 Mar;7(3):1327-38 IF= 4.824,

25.Jodynis-Liebert J, Nowicki M., Murias M., Adamska T., Ewertowska E, Kujawska M., Piotrowska H., Konwerska A, Ostalska-Nowicka D., Pernak Cytotoxicity, acute and subchronic toxicity of ionic liquid, didecyldimethylammonium saccharinate, in rats. J. Regul. Toxicol. Pharmacol. 2010 Vol. 57 nr 2-3 s. 266-27 IF=2.162,

26.Kroll P, Jankowski A, Soltysiak J, Murias M, Skrzypczak M, Zachwieja J, Botulinum Toxin-A Injections in Children with Neurogenic Bladder, 2009 Nephro-Urology Monthly, 3(2), 125-128

27.M. Rüweler, M. Gülden M.E Maser, M. Murias, H. Seibert. Cytotoxic, cytoprotective and antioxidant activities of resveratrol and analogues in C6 astroglioma cells in vitro. Chem. Biol. Interact. 2009 Dec 10;182(2-3):128-35. IF=2.457

28.M. Kujawska, E. Ignatowicz, M. Murias, M. Ewertowska, K. Mikołajczyk, J.Jodynis-Liebert. Protective effect of red beetroot against carbon tetrachloride- and N-nitrosodiethylamine-induced oxidative stress in rats. J. Agric. Food Chem. 2009 Vol. 57 nr 6 s. 2570-2575. IF= 2.162

29.P. Kroll, A. Jankowski, A. Antczak, J. Zachwieja, M. Zaniew, M. Murias, M. Skrzypczak. The efficiency of endoscopic augmentation in the capacity of neurogenic urinary bladder in children using Botulinum Toxin-A. Polish. Journal of. Environmental. Studies. 2008 Vol. 17 nr 4A s. 224-228

30.P. Kroll, A. Jankowski, A. Antczak, J. Zachwieja, M. Zaniew, M. Murias, M. Skrzypczak. The efficiency of endoscopic augmentation in the capacity of neurogenic urinary bladder in children using Botulinum Toxin-A. Pol. J. Environ. Stud. 2008 Vol. 17 nr 4A s. 224-228

31.M. Murias, MW Luczak, A Niepsuj, V. Krajka-Kuzniak, M Zielinska-Przyjemska, PP Jagodzinski, W Jäger, T Szekeres, J Jodynis-Liebert. Cytotoxic activity of 3,3',4,4',5,5'-hexahydroxystilbene against breast cancer cells is mediated by induction of p53 and downregulation of mitochondrial superoxide dismutase. Toxicol in Vitro. 2008 Aug;22(5):1361-70. IF= 2.473

32.M Murias, M Miksits, S Aust, M Spatzenegger, T Thalhammer, T Szekeres, W Jaeger. Metabolism of resveratrol in breast cancer cell lines: impact of sulfotransferase 1A1 expression on cell growth inhibition. Cancer Lett. 2008 Mar 18;261(2):172-82. IF= 3.504

33.L. Kedzierski, JM Curtis, M. Kaminska, J. Jodynis-Liebert, M. Murias. In vitro antileishmanial activity of resveratrol and its hydroxylated analogues against Leishmania major promastigotes and amastigotes. Parasitol Res. 2007 Dec;102(1):91-7. IF= 1.512

34.P. Saiko, Z. Horvath, M. Murias, N. Handler, W. Jaeger, T. Erker, M. Fritzer-Szekeres, T. Szekeres. Antitumor effects of 3,3',4,4',5,5'-hexahydroxystilbene in HL-60 human promyelocytic leukemia cells. Nucleosides Nucleotides Nucleic Acids 2006, 25(9): 1013-101 IF=0.671

35.Z. Horvath, M. Murias, P. Saiko, T. Erker, N. Handler, S. Madlener, W. Jaeger, M. Grusch, M. Fritzer-Szekeres, G. Krupitza, T. Szekeres. Cytotoxic and biochemical effects of 3,3',4,4',5,5'-hexahydroxystilbene, a novel resveratrol analog in HL-60 human promyelocytic leukemia cells. Experimental. Hematology. 2006, 34( 10):1377-1384 IF=3.408

36.J. Jodynis-Liebert, W. Bylka, I. Matlawska and M. Murias Protective effect of Aquilegia vulgaris L on aflatoxin B1-induced hepatic damage in rats, Environmental Toxicology and Pharmacology, 2006, 22(1); 58-63

37.J. Dudka, M. Murias, F. Burdan, J. Szumilo, E. Tokarska, A. Korobowicz, R. Klepacz, J. Jodynis-Liebert, E. Korobowicz. An in vitro evaluation of NADPH-cytochrome P-450 reductase activity in microsomes of selected human organs in the presence of Ukrain and Padma 28. Polish. Journal of. Environmental. Studies. 2006 15 (5b): 675-679 IF=0.353

38.J. Dudka, M. Murias, F. Burdan, J. Szumiło, A. Korobowicz, E. Tokarska, L. Wronecki, R. Klepacz, M. Klepacki, J. Jodynis-Liebert, E. Korobowicz. Effect of green tea on NADPH-cytochrome P-450 reductase activity in selected human organs. Ann Univ Mariae Curie Sklodowska, Sectio D 2006, 61(2): 649-654

39.J. Dudka, M. Murias, J. Jodynis-Liebert, L. Wronecki, F. Burdan, J. Szumilo, R. Klepacz, A. Korobowicz, E. Tokarska, M. Kotarska E. Korobowicz, Inhibition of the human heart and lung NADPH-cytochrome P-450 reductase activity at the presence of 4-methylpyrazole. Ann Univ Mariae Curie Sklodowska, Sectio D, 2005, 60(2): 535-538

40.J. Jodynis-Liebert, W. Bylka, I. Matlawska and M. Murias, Antioxidant activity of Aquilegia vulgaris in CCl4-induced liver injury in rats Recent Progress in Medicinal Plants vol 14

41.M. Murias, J. Jodynis-Liebert, W. Bylka, I. Matlawska. Antioxidant activity of isocytisoside and extracts from Aquilegia vulgaris. Fitoterapia 2005, 76:476-80. IF=0845

42.M. Murias, M. Rachtan, J. Jodynis-Liebert, Effect of multiple freeze-thaw cycles of cytoplasm samples on the activity of antioxidant enzymes. Journal of Pharmacological and Toxicological Methods. 2005, 52:302-5

43.J. Dudka, J. Jodynis-Liebert, E. Korobowicz, F. Burdan, A Korobowicz, J.Szumilo, E. Tokarska, R. Klepacz and M. Murias Activity of NADPH-cytochrome P-450 reductase of the human heart, liver and lungs in the presence of (-)-epigallocatechin gallate, quercetin and resveratrol – an in vitro study, Basic and Clinical Pharmacology and Toxicology, 2005, 97:74-9 IF=1.486

44.M. Murias, N. Handler, T. Erker, P. Saiko, T. Szekeres, L. Gille, H. Nohl, and W. Jäger: Antioxidant and antitumor activity of resveratrol analogues – structure activity relationship, Biochemical Pharmacology, 2005,69:903-912 IF=3.617

45.J. Jodynis-Liebert, W. Bylka, I. Matlawska and M. Murias. Protective effect of Aquilegia vulgaris (L.) on APAP-induced oxidative stress in rats. Journal of Ethnopharmacology, 2005;97:351-358 IF=1.554

46.M. Murias, N. Handler, T. Erker, K. Pleban, G. Ecker, P. Saiko, T. Szekeres, W. Jäger. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure–activity relationship Bioorganic and Medicinal Chemistry, 2004,12:5571-78 IF=2.081

47.M. Kujawska and M. Murias. Paracetamol – ethanol. Complicated interaction. Advances in Clinical and Experimental Medicine, Review, [Polish], 2004, 13: 497-501

48.J. Jodynis-Liebert, M. Murias. Modulation of antioxidant defence system by dietary fat in rats intoxicated with o-toluidine. Human and Experimental Toxicology. 2002,21:659-65. IF=0.954

49.M. Murias, J.Jodynis-Liebert, W. Baer-Dubowska. The effect of cytochrome P-450 inducers and phenolic antioxidants on lipid peroxidation and glutathione peroxidase in rat liver and kindey. Acta Poloniae Toxicologica. 2000,8:33-43.

50.J. Jodynis-Liebert, M. Murias, E. Bloszyk. Effect of sesquiterpene lactones on antioxidant enzymes and some drug-metabolizing enzymes in rat liver and kindey. Planta Medica. 2000,66:199-205. IF=1.831

51.J. Jodynis-Liebert, M. Murias, E. Bloszyk. Effect of several sesquiterpene lactones on lipid peroxidation and glutathione level. Planta Medica. 1999,65:320-324 IF=1.438

*These papers are results of M. Curie Fellowship and M.Curie Reintegration Grant founded by European Commission as a part of 5th and 6th Framework Programs.


  1. Institute of Pharmaceutical Chemistry, University of Vienna,
  2. Institute of Pathophysiology, Medical University of Vienna,
  3. Institute of Pharmacology and Toxicology, Veterinary University of Vienna,
  4. Clinical Institute of Medical Diagnostics, Medical University of Vienna,
  5. Institute of Toxicology and Pharmacology for Natural Scientists, University Medical School Schleswig-Holstein, Kiel, Germany,
  6. Infection and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia

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